Clinical Features of Scleritis Across the Asia-Pacific Region

ABSTRACT

Purpose: To examine the spectrum of scleritis in four tertiary institutions across the Asia-Pacific.

Methods: Clinical records from 354 patients were reviewed from centers in Australia, Singapore, and India, excluding those with insufficient data (n = 24).

Results: Indian patients presented younger (41.5 ± 13.4 years) than Australians (50.8 ± 17.5) and Singaporeans (48.6 ± 15.9), with fewer women (49% vs 62%/57%). Diffuse disease was universally most common. Autoimmune and infectious disease proportions were similar in Australia (31%/10.3%) and Singapore (27.5%/8.3%) but reversed in India (8.3%/30%). Necrotizing scleritis was most frequently associated with infection (27.3%). Presumed ocular tuberculosis accounted for 75% of infectious cases in India. Posterior scleritis had the highest complication rate (82.4%) and immunosuppressants used per patient (0.98 ± 0.31 95% CI).

Conclusions: Clinical presentations of scleritis vary across the Asia-Pacific, particularly in endemic regions for tuberculosis such as India, where it affects younger men with a predominance of nodular and infectious disease.

Keywords:

• Asia-Pacific
• autoimmune scleritis
• diffuse anterior scleritis
• infective scleritis
• necrotizing anterior scleritis
• nodular anterior scleritis
• posterior scleritis
• scleritis

Disclosure of Interest

The authors report no conflict of interest. The authors alone are responsible for the content and writing of the paper.