Increased Systemic Immune-Inflammation Index Levels in Patients with Dry Eye Disease

ABSTRACT

Purpose

To evaluate the systemic immune-inflammation index (SII) levels, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) in patients with dry eye disease (DED) and to compare with control subjects.

Methods

This prospective study included 47 DED patients and 47 age- and sex-matched healthy controls. Ophthalmological examination, diagnostic DED tests, and routine complete blood cell count parameters were analyzed. The SII value was calculated as follows: platelet count × (neutrophil/lymphocyte).

Results

The mean SII, NLR, and PLR levels were significantly higher in DED patients compared to controls (p < .001, p < .001 and p = .009, respectively). Using the receiver operating characteristics (ROC) curve analysis to predict patients with DED, the highest area under the curve (AUC) was determined SII (0.761 for SII, 0.727 for NLR, and 0.653 for PLR).

Conclusions

As a novel tool superior to other inflammatory markers, SII may be a cheap and reliable indicator of inflammatory status in DED patients.

KEYWORDS:

• Systemic immune-inflammation index
• dry eye disease
• inflammation
• neutrophil-to-lymphocyte ratio
• platelet-to-lymphocyte ratio

Declaration of Interest

No conflict of interest was declared by the authors.

We stipulate that all persons listed as authors have contributed to preparing the manuscript. The manuscript has been read and approved by all the authors and each author believes that the manuscript represents honest work.

Additional information

Funding

The authors state that there is no funding to declare.