Idiopathic Vitritis after Boston Type 1 Keratoprosthesis Implantation: Incidence, Risk Factors and Outcomes in a Multicentric Cohort

ABSTRACT

Purpose

To determine incidence, risks factors for, and outcomes of idiopathic vitritis (IV) after Boston type 1 keratoprosthesis (KPro) implantation.

Methods

Retrospective, consecutive case series. Risk factors were analyzed between IV group and No IV group.

Results

IV occurred in 32/350 procedures (9.1%), for an average incidence of 0.02 cases per procedure-year. Presumed infectious keratitis was the only risk factor identified (HR = 7.65) Corneal necrosis and retinal detachment occurred significantly more frequently in IV group (all P < .05). By last follow-up, the cumulative proportion of eyes that maintained a visual acuity >20/200 was significantly lower in IV group (P = .01), as was the KPro retention rate (HR = 0.26).

Conclusions

IV is associated with infectious keratitis, indicating that the vitritis may not be a sterile process. The increased incidence of subsequent complications leads to significantly decreased visual acuity and KPro retention in affected eyes.

KEYWORDS:

• Boston type 1 keratoprosthesis
• cornea
• corneal melt
• infectious keratitis
• idiopathic vitritis
• retinal detachment
• risk factor

Disclosure of Interests

None of the authors has a financial interest related to this manuscript.

Additional information

Funding

Supported by an unrestricted grant from Research to Prevent Blindness, which had no role in the design or conduct of this research.