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Invited Review

A Review of Ocular Graft-versus-Host Disease: Pathophysiology, Clinical Presentation and Management

, MD, , MDORCID Icon, , MD, , MD, PhD, MPHORCID Icon & , MD, MSc, MPH
Pages 1190-1199 | Received 15 Jan 2021, Accepted 01 Jun 2021, Published online: 06 Jul 2021
 

ABSTRACT

Graft-versus-host disease is a common complication following allogeneic hematopoetic stem cell transplantation that can affect multiple organ systems, including the eyes. Ocular GVHD (oGVHD) is characterized by a T cell-mediated immune response that leads to immune cell infiltration and inflammation of ocular structures, including the lacrimal glands, eyelids, cornea and conjunctiva. oGVHD has a significant negative impact on visual function and quality of life and successful management requires a multi-disciplinary approach with frequent monitoring. Here, we review the pathophysiology and clinical presentation of oGVHD, along with current therapeutic strategies based on our clinical experience and the reported literature.

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

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