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Ocular Immunology and Inflammation Volume 31, 2023 - Issue 3
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Letters to the Editor

Paracentral Acute Middle Maculopathy in A Young Girl Treated with Interferon-Beta for Nasopharyngeal Carcinoma

Chiara Giuffrèa Manchester Royal Eye Hospital, Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UKCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-0839-2670View further author information
, MD, FEBOORCID Icon,
Sara Syeda Manchester Royal Eye Hospital, Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UKView further author information
, MB BChir, MA, PGCE,
Sasa Pockara Manchester Royal Eye Hospital, Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UKView further author information
, MD,
Jane L Ashwortha Manchester Royal Eye Hospital, Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK;b Faculty of Biology, Medicine & Health, University of Manchester, Manchester, UKView further author information
, BMBCh, FRCOphth, PhD &
Laura R Steeplesa Manchester Royal Eye Hospital, Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK;b Faculty of Biology, Medicine & Health, University of Manchester, Manchester, UKView further author information
, MBChB
Pages 589-593 | Received 08 Jul 2021, Accepted 13 Jan 2022, Published online: 24 Feb 2022
 
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ABSTRACT

Purpose

To describe a case of interferon-beta retinopathy associated with paracentral acute middle maculopathy

Case report

A 15-year-old girl with Epstein–Barr virus-positive advanced nasopharyngeal carcinoma WAS REFERRED with reduced visual acuity. Multimodal imaging findings, including optical coherence tomography angiography, at presentation and evolution following cessation of interferon therapy are presented.

Conclusion

The presentation of paracentral acute middle maculopathy in this patient supports the presumed ischaemic pathogenesis in interferon retinopathy. The imaging findings provide evidence of deep capillary plexus involvement in interferon retinopathy with evolution to permanent structural damage within the inner nuclear layer.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The author(s) reported that there is no funding associated with the work featured in this article.

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