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ABSTRACT
A study was designed to comparatively assess the impact of summer season induced heat stress on the immune response related genes in two different indigenous Osmanabadi and Salem Black goat breeds. The primary objective of the study was to elucidate the impact of heat stress on the different intracellular toll-like receptors expression pattern in both these goat breeds. The results indicated that the expression of TLR3 and TLR7 followed the same pattern between both Osmanabadi and Salem Black breeds with significantly higher expression in heat stress group of both these breeds. However, TLR8 and TLR9 genes showed different expression patterns between the breeds with significantly higher expression of these two genes recorded in the Salem Black breed. Based on the preliminary findings in the current study, it can be concluded that Salem Black breed possesses a better thermo-tolerance capacity as compared to Osmanabadi breed which is native to the study location.
Abbreviations: TLR: Toll-like receptors; IPCC: Inter Governmental Panel on Climate Change; THI: Temperature-humidity Index; HSP: Heat Shock Protein; MLN: Mesenteric Lymph Node; GHG: Greenhouse Gases; RTqPCR: Real Time quantitative polymerase chain reaction; ANOVA: Analysis of Variance; ACTH: Adreno-corticotropic hormone; HPA: Hypothalamo-Pituitary Adrenal Axis.
Acknowledgments
The authors are more grateful to the Director, ICAR-National Institute of Animal Nutrition and Physiology for providing the research facilities to complete this study. The authors also highly thankful to the Indian Council of Agricultural Research (ICAR) for providing the funding for this research work.
Disclosure statement
No potential conflict of interest was reported by the authors.