Association between the vascular endothelial growth factor gene polymorphisms and the risk of polycystic ovary syndrome in Northern Chinese women

Abstract

The present study aimed to investigate whether the single nucleotide polymorphisms (SNPs) rs2010963 and rs833061 in vascular endothelial growth factor (VEGF) gene is correlated with the risk of polycystic ovary syndrome (PCOS) in Northern Chinese women, as a preliminary study. This case-control study comprised 118 women with PCOS and 130 healthy women as controls. Genotyping of the two polymorphisms within the VEGF gene 5′-untranslated region and promoter region were performed using polymerase chain reaction ligase detection reaction method. The data showed that there was a significant difference in the genotype and allele distribution of the rs2010963 polymorphism between the PCOS group and the control group (p = .020 and .033, respectively). The women carrying the C allele (G/C + C/C genotype) had a lower risk of PCOS compared with the women with G/G genotype [odds ratio (OR = 0.55; 95% confidence interval (CI) = 0.33–0.91]. Our study shows for the first time that the rs2010963 polymorphism may be associated with a risk of PCOS in Northern Chinese women.

摘要

本研究旨在初步研究中国北方女性血管内皮生长因子（VEGF）基因中的单核苷酸多态性（SNPs）rs2010963和rs833061是否与多囊卵巢综合征（PCOS）风险相关。本病例对照研究包括118名患有多囊卵巢综合症的女性和130名健康对照组女性。采用聚合酶链反应连接酶检测反应法对血管内皮生长因子基因5’-未翻译区和启动子区进行两个多态性的基因分型。数据表明, 多囊卵巢综合征组与对照组rs2010963多态性的基因型和等位基因分布存在显著差异（分别P = 0.020和0.033）。携带C等位基因（G/C + C/C基因型）的妇女与携带G/G基因型的妇女相比, 患多囊卵巢综合征的风险较低[比值比（OR）=0.55；95%置信区间（CI）=0.33–0.91]。我们的研究首次表明, rs2010963多态性可能与中国北方女性患多囊卵巢综合症的风险有关。

The Chinese abstracts are translated by Prof. Dr. Xiangyan Ruan and her team: Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.

Keywords:

• Polycystic ovary syndrome
• vascular endothelial growth factor gene
• single nucleotide polymorphism
• risk
• susceptibility

Disclosure statement

No potential conflict of interest was reported by the authors.