The relationship between elevated serum xenin and insulin resistance in women with polycystic ovary syndrome: a case-control study

Abstract

This study aims to determine whether serum xenin-25 levels are altered in women with polycystic ovary syndrome (PCOS). The study included 31 women diagnosed with PCOS according to the 2003 Rotterdam criteria and 30 healthy controls. The primary outcome was serum xenin-25 levels. Other variables evaluated were menstrual history, physical findings, Ferriman-Gallwey hirsutism score, blood pressure, transvaginal ultrasonography, fasting blood glucose, insulin, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, C-reactive protein, follicle stimulating hormone, luteinizing hormone, estradiol, total testosterone, dehydroepiandrosterone sulfate, and day-21 progesterone. Median (min–max) values of xenin-25 were 45.50 pg/mL (7.10–656.40) and 9.85 pg/mL (7.00–564.40) for cases and controls, respectively, demonstrating a significant difference (Z = 2.803, p = .007). The ROC curve for xenin-25 predicting the PCOS risk had an area under the curve of 0.747. The optimal cutoff value of xenin-25 for detecting PCOS was calculated as ≥32.60 pg/mL with sensitivity, specificity values of 61.3% and 86.7%, respectively. A logistic regression model including xenin-25, FSH, Ferriman-Gallwey score, and Menstrual cycle frequency demonstrated the independent relationship of xenin-25 on PCOS (p < .05). This study demonstrated that xenin-25 may contribute to the diagnosis of PCOS. Further studies are needed to fully elucidate the effects of xenin-25 in the pathogenesis of PCOS.

摘要

本研究的目的是为了确定多囊卵巢综合征（PCOS）患者血清中xenin-25水平是否发生改变。该研究纳入31名依据2003年鹿特丹标准诊断为多囊卵巢综合征女性和30名健康对照者。主要结果是血清xenin-25水平。其他变量为月经史、体格检查、Ferriman-Gallwey多毛症评分、血压、阴道超声、空腹血糖、胰岛素、总胆固醇、低密度脂蛋白、高密度脂蛋白、甘油三酯、C反应蛋白、促卵泡素、促黄体生成素、雌二醇、总睾酮、脱氢表雄酮及第21天黄体酮。病例组和对照组的xenin-25中位数分别为45.50pg/mL(7.10–656.40)和9.85pg/mL (7.00–564.40), 差异有统计学意义 (Z=2.803, p=0.007)。xenin-25预测PCOS风险的ROC曲线下面积为0.747。xenin-25预测PCOS的最佳截断值为≥32.60pg/mL, 灵敏度61.3%, 特异度为86.7%。包括xenin-25、FSH、Ferriman-Gallwey评分、月经周期在内的Logistic回归模型显示xenin-25与PCOS呈独立关系（p<.05）。本研究表明, xenin-25可能有助于PCOS的诊断。进一步的研究需要充分阐明xenin-25在PCOS发病机制中的作用。

The Chinese abstracts are translated by Prof. Dr. Xiangyan Ruan and her team: Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.

Keywords:

• Polycystic ovary syndrome
• hormones
• case-control studies

Disclosure statement

The authors have no conflict of interest in this study.