The sequential embryo transfer compared to blastocyst embryo transfer in in vitro fertilization (IVF) cycle in patients with the three repeated consecutive IVF. A randomized controlled trial

Abstract

The purpose of this study was to determine the pregnancy rate in the double sequential transfer of embryos on both day 3 and day 5 compared to day 5 alone, in in vitro fertilization-embryo transfer (IVF/ET) in patients with the three repeated consecutive IVF failures. In this controlled trial, women scheduled for IVF/ET with the three repeated consecutive IVF failures were randomized to either sequential transfer of embryos on day 2 and on day 5 after ovum pick-up (group 1, n = 60) or blastocyst ET on day 5 (group 2, n = 60) as a control group. The primary outcome measures were the chemical and clinical pregnancy rate. Baseline and cycle characteristics were comparable in both groups. Chemical and clinical pregnancy rate was similar in the sequential ET group (40%) compared to the day 5 of ET group (38.3%) (p value = .85). It seems that the double ET does not increase the chance of pregnancy rate compared to blastocyst ET on day 5 in the patients with the three repeated IVF-ET failures.

摘要

此研究的目的是对连续反复三个IVF/ET周期失败患者应用第3天和第5天的二步法（序贯）胚胎移植与仅第5天囊胚移植之间妊娠率的比较。这项对照试验中, 将连续三个反复IVF/ET周期失败患者随机分组, 取卵后第3天和第5天的序贯的胚胎移植（1组, n=60）, 第5天囊胚移植作为对照组(2组, n=60)。主要的结局指标为生化妊娠率和临床妊娠率。两组的基线和周期特征相当。序贯ET组的生化和临床妊娠率（40％）与第5天ET组（38.3％）相似（p值=.85）。连续三个IVF/ET治疗周期反复失败患者应用二步法ET与第5天囊胚ET相比可能不增加妊娠率。

The Chinese abstracts are translated by Prof. Dr. Xiangyan Ruan and her team: Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.

Keywords:

• Repeated implantation failure
• blastocysts
• day 3 embryo transfer
• sequential transfer
• randomized clinical trial

Acknowledgments

The authors are grateful to the Infertility Center of Vali Asr Hospital affiliated to Tehran University of Medical Sciences for helping them. It should be noted that there was no association between the authors and any organization or institution.

This article is a residential thesis and was approved by Tehran University of Medical Sciences, IRAN (IR.TUMS.IKHC.REC.1396.3849).

Disclosure statement

No potential conflict of interest was reported by the authors.