Abstract
To assess clinical outcomes of females diagnosed with Inflammatory Bowel Disease (IBD) and infertility, which underwent in vitro fertilization (IVF) with preimplantation genetic testing for aneuploidy. (PGT-A). Retrospective cohort study comparing clinical outcomes of patients with Inflammatory bowel disease who underwent IVF with PGT-A with a subsequent euploid single embryo transfer (SET) against a matched control group. Thirty-eight patients with an IBD diagnosis were compared to 114 controls. There was no significant difference in cycle outcomes among IBD and Control cohorts [implantation rate (71.0% vs. 78.0% (p = .68)], clinical pregnancy rate [50.0% vs. 60.5% (p = .68)], live birth [62.9% vs. 73.0% (p = .06)] multiple pregnancy rate [0% vs. 1.1% (p = .25)] and clinical pregnancy loss rate [10.5% vs. 5.7% (p = .54)]. An IBD diagnosis was not found to significantly modify the odds of implantation [adjusted OR = 0.6 (95% CI −1.2 to 0.8)]. Additionally, the odds of implantation in patients with IBD were not altered by having ulcerative colitis or Crohn’s disease diagnosis. (OR = 0.4 95% CI 0.1–1.9). Patients diagnosed with IBD who undergo a SET have clinical outcomes comparable to the general infertile population. Patients and physicians can be reassured that an IBD diagnosis does not impair IVF treatment outcomes.
Infertile patients with inflammatory bowel disease who utilized a single, euploid blastocyst transfer had IVF success rates comparable to the general infertile population.
SYNOPSIS
摘要
目的探讨非整倍体植入前基因检测(PGT-A)在体外受精(IVF)中诊断为炎症性肠病(IBD)和不孕症的女性患者的临床结局。回顾性队列研究比较炎症性肠病患者行PGT-A体外受精和随后的单胚胎全倍体移植(SET)与对照组的临床结果。38例诊断为IBD的患者与114例对照组进行比较。IBD组和对照组的周期结局无显著差异[植入率(71.0% vs 78.0%(p=.68)], 临床妊娠率[50.0% vs 60.5%(p=0.68)]、活产率[62.9% vs 73.0%(p=0.06)]、多胎妊娠率[0% vs 1.1%(p=0.25)]、临床妊娠丢失率[10.5% vs 5.7%(p=0.54)]。IBD的诊断并没有显著改变植入的几率[校正OR=0.6(95%CI-1.2∼0.8)]。此外, IBD患者的植入几率并没有因为溃疡性结肠炎或克罗恩病的诊断而改变(OR=0.4 95%置信区间0.1–1.9)。被诊断为IBD的患者接受SET的临床结果与一般不育人群相当。病人和医生可以放心的是IBD的诊断不会损害IVF的治疗效果。
The Chinese abstracts are translated by Prof. Dr. Xiangyan Ruan and her team: Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.
Acknowledgements
The authors thank the physicians, fellows, embryologists, research and other staff members at the study site and affiliated hospital for their valuable work and help in contribution to the development of this manuscript.
Disclosure statement
The authors report no conflict of interest.