Does metformin affect mammographic breast density in postmenopausal women with type 2 diabetes

Abstract

Background: Increased mammographic breast density (MBD) is known to be associated with an increased risk of developing breast cancer.

Aims: In this study, we aimed to research the possible relationship between MBD and metformin use in postmenopausal women diagnosed with type 2 diabetes mellitus (T2DM).

Method: The patients were divided into two groups: women with T2DM and who were on metformin and women who were newly diagnosed with T2DM and had not yet taken metformin. MBD types are evaluated by a specialist radiologist.

Results: Among the 74 women, 32 (43.2%) were in the group that did not use metformin and 42 (56.8%) were in the group of patients using metformin. The duration of breastfeeding (p = .0003), fasting blood glucose (p = .0003) and HbA1c (p = .0006) were statistically significantly higher in the group not using metformin. The quantitative mean ranks of the group members’ MBD’s were 41.81 in the metformin naïve group and 34.21 in the group using metformin (p = .12).

Conclusions: In conclusion, metformin has no statistically significant effect on MBD in postmenopausal female patients with T2DM.

摘要

背景：已知乳腺X线摄影的乳房密度(MBD)的增加与乳腺癌发生风险增加有关。

目的：本研究旨在研究诊断为2型糖尿病(T2DM)的绝经后女性MBD与二甲双胍应用的可能关系。

方法：将患者分为两组, 一组为服用二甲双胍的2型糖尿病患者, 另一组为新诊断为2型糖尿病的未服用二甲双胍的患者。MBD类型由专业放射科医生评估。

结果：在74名女性中, 未服用二甲双胍组32名(43.2%), 服用二甲双胍组42名(56.8%)。未服用二甲双胍组的母乳喂养时间(p＝.0003)、空腹血糖(p＝.0003)和糖化血红蛋白(p＝.0006)显著更高。未服用二甲双胍组其MBD定量平均秩为41.81, 服用二甲双胍组为34.21（p＝0.12）。

结论：综上所述, 二甲双胍对绝经后女性2型糖尿病患者的MBD在统计学上无影响。

The Chinese abstracts are translated by Prof. Dr. Xiangyan Ruan and her team: Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.

Keywords:

• Metformin
• mammography
• density
• diabetes
• menopause

Disclosure statement

No potential conflict of interest was reported by the author(s).