Abstract
We aimed to evaluate whether or not time lapse selection was beneficial for the cleavage-stage embryo transfers. The study included 838 infertile women with good ovarian reserve (obtaining more than 8 oocytes) from January 2018 to August 2019. Based on the transferred embryos with different grades (grade I, II and III), the patients were divided into day 3 selection with conventional morphology (CM) and day 3 selection with time lapse (TL) groups. For the grade I and II embryos, we observed that CM and TL had similar implantation, clinical pregnancy and ongoing pregnancy (p > .05) rates. For the grade III embryos, we observed that CM group showed slightly lower implantation (36.74 versus 41.03%, p = .261) and clinical pregnancy (56.82 versus 64.10%, p = .182) rates than TL group. CM group showed significantly lower ongoing pregnancy (47.35 versus 59.83%, p = .025) rate than TL group. And we observed that CM group had significantly higher blastulation (38.93 versus 26.61%, p = .019) rate than TL group. We concluded that TL selection was beneficial to the patients with no good-quality embryos in the first cleavage-stage embryo transfers.
摘要
我们旨在评估延时选择是否对卵裂期胚胎移植有益。该研究纳入了从2018年1月至2019年8月的838名具有良好卵巢储备功能(获得8个以上的卵母细胞)的不育妇女, 并进行了相关研究。根据不同等级(I, II和III级)移植的胚胎, 将患者分为第3天常规形态学(conventional morphology, CM)选择组和第3天延时(time lapse, TL)选择组。对于I级和II级胚胎, 我们观察到CM和TL具有相似的着床、临床妊娠和持续妊娠率 (p > .05)。对于III级胚胎, 我们观察到CM组与TL组相比, 着床率(36.74%与41.03%, p=0.261)和临床妊娠率(56.82%与64.1%, p=0.182)略低。CM组持续妊娠率明显低于TL组(47.35%与59.83%, p=0.025)。CM组的囊胚形成率显著高于TL组(38.93%与26.61%, p=0.019)。我们的结论是, TL选择对首次分裂期胚胎移植中胚胎质量不佳的患者是有利的。
Disclosure statement
No potential conflict of interest was reported by the author(s).