Abstract
Both environmental and genetic factors interact and play a critical role in the pathogenesis of endometriosis. We analyzed the plasma levels of 12 polychlorinated biphenyl (PCB) congeners with genetic polymorphisms of glutathione-S-transferase M1 (GSTM1), glutathione-S-transferase T1 (GSTT1), and aryl hydrocarbon receptor repressor (AhRR) codon 185. Total sum of the 12 congeners was significantly higher in the controls compared with endometriosis group. Women without C/C genotype in AhRR codon 185 had a significantly increased risk of endometriosis compared with those with C/C genotype. Total sum of the 12 congeners was significantly higher in women without C/C genotype compared with those with C/C genotype. Adjusting for age and AhRR codon 185 genotype, there was no significant association between exposure to PCBs and the risk of endometriosis. These findings suggest a possible presence of gene-environment interaction, however, we could not see any clear association between exposure to PCBs and the risk of endometriosis.
摘要
环境因素和遗传因素的相互作用在子宫内膜异位症的发病机制中起重要作用。我们分析了12个具有遗传多态性的多氯联苯(PCB)同系物的血浆水平, 它们都包含谷胱甘肽-S-转移酶M1(GSTM1)、谷胱甘肽-S-转移酶T1(GSTT1)和芳香受体抑制因子(AhRR)密码子185。与子宫内膜异位症组相比, 对照组12种多氯联苯同系物的浓度均显著升高。AhRR密码子185中, 无C/C基因型比有C/C基因型的女性患子宫内膜异位症的风险显著增加。无C/C基因型的女性12种同源基因的总和明显高于有C/C基因型的女性。调整年龄和AhRR密码子185基因型, 暴露于多氯联苯与子宫内膜异位症风险之间没有显著相关性。这些发现表明可能存在基因与环境的相互作用, 但是我们还没有发现暴露于多氯联苯与子宫内膜异位症风险之间有任何明确的关系。
The Chinese abstracts are translated by Prof. Dr. Xiangyan Ruan and her team: Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.
Disclosure statement
The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.