Abstract
Aims
To evaluate the effect of serum and follicular fluid (ff) Chemerin levels on Assisted Reproductive Technology (ART) outcomes in lean patients with PCOS.
Materials and methods
The study included 76 infertile reproductive aged women, between 21–35 years who underwent intracytoplasmic sperm injection (ICSI) procedure. Serum and ff Chemerin levels were evaluated. Fertilization and clinical pregnancy rate were compared between the groups.
Results
Serum (13.32 ng/ml versus 29.82 ng/ml) and ff chemerin (35.90 ng/ml versus 87.60 ng/ml) levels were significantly higher in lean PCOS patients compared to controls (p < .01). Serum (24.5 ng/ml versus 18.4 ng/ml) and ff chemerin (71.7 ng/ml versus 52.8 ng/ml) levels were higher in subjects without clinical pregnancy compared to the subjects with clinical pregnancy (p < .05). A cutoff value of 36.2 ng/ml in the ff chemerin level was found to estimate clinical pregnancy with 83% sensitivity and 52% specificity (Area under the curve 0.66; 95% confidence interval, 0.53–0.79). A cutoff value of 12.7 ng/ml in the serum chemerin level was found to estimate clinical pregnancy with 91% sensitivity and 49% specificity (Area under the curve 0.65; 95% confidence interval, 0.52–0.78). Clinical pregnancy rates were significantly higher in group with lower serum chemerin levels (80.0% versus 30.4%, p < .001). High serum chemerin levels are associated with failure of assisted reproduction [OR:0.1(95% CI, 0.03–0.4, p < .001)].
Conclusions
PCOS is associated with higher serum and ff chemerin levels and high serum chemerin level is a risk factor for failed ART cycle.
血清和卵泡液中趋化素浓度在多囊卵巢综合征辅助生殖周期中的预测价值 摘要
目的:评估血清和卵泡液(ff)中趋化素水平在瘦PCOS患者辅助生殖技术(ART)结局中的作用。
材料与方法:研究纳入了76名21-35岁行单精子注射(ICSI)的不孕生育年龄女性。测量血清和ff趋化素水平。比较组间受精和临床妊娠率。
结果:瘦PCOS患者血清(13.32ng / ml与29.82ng / ml)和ff 趋化素(35.90ng / ml与87.60ng / ml)的水平显著高于对照组(p <.01)。未临床妊娠的受试者其血清(24.5ng / ml与18.4 ng / ml)和ff 趋化素(71.7ng / ml与52.8ng / ml)水平高于已临床妊娠的受试者(p <.05)。以36.2ng / ml为ff 中趋化素的截断值, 敏感度为83%, 特异度为52%(曲线下面积为0.66; 95%可信区间为0.53-0.79)。以12.7ng / ml为血清趋化素水平的截断值, 预测临床妊娠的敏感度为91%, 特异度为49%(曲线下的面积0.65; 95%可信区间, 0.52-0.78)。在血清趋化素水平较低组中临床妊娠率显著更高(80.0%与30.4%, P <.001)。血清趋化素水平高与辅助生殖失败相关[OR:0.1(95% CI, 0.03–0.4, p<.001)]。
结论:PCOS与较高的血清和ff 趋化素水平相关, 并且血清趋化素水平高是ART周期失败的危险因素。
Disclosure statement
No potential conflict of interest was reported by the author(s).