Supernumerary embryos, do they show the cycle success in a fresh embryo transfer? A retrospective analysis

Abstract

Objective

To determine the predictive value of cryopreserved embryos during single fresh blastocyst transfer

Methods

This retrospective cohort study was conducted at a tertiary university hospital ART center. Patients who underwent a single fresh blastocyst transfer were selected from the electronic database. Patients with diminished ovarian reserve, uterine pathology, advanced age (>40 years) were excluded from the study. Patients were divided into two groups. Group A consisted of patients with only one available embryo for the fresh transfer. Group B consisted of patients with cryopreserved embryos apart from the fresh transferred embryo. Demographic and embryology parameters, pregnancy results were compared.

Results

Demographic values, ovarian reserve parameters were comparable between groups. The number of the picked-up oocyte, metaphase-2 oocyte, and two-pronucleus embryo was lower in Group A. Positive pregnancy rates were two-fold higher in Group B (23.4% vs. 50.9% p < .01). Pregnancy results did not change depending on the number of cryopreserved embryos in Group B.

Conclusion

According to our results, the presence of cryopreserved embryos results in higher pregnancy rates in patients with fresh blastocyst embryo transfer independent from the woman’s age and ovarian reserve. Thus, these results may help us to predict the implantation rate before embryo transfer.

多余胚胎是否可以预测新鲜胚胎移植周期的成功？一项回顾性分析 摘要

目的：探究冷冻胚胎数量在单次新鲜囊胚移植是否成功中的预测价值。

方法：这项回顾性队列研究是在一家三级大学医院辅助生殖中心进行的。从电子数据库中选择接受单一新鲜囊胚移植的患者。研究排除卵巢储备功能减退、子宫病变、高龄（>40岁）的患者。患者被分为两组, A组为只有一个可用胚胎进行新鲜移植的患者, B组为除新鲜移植胚胎外还有冷冻胚胎的患者。对两组人口学和胚胎学参数、妊娠结局进行了比较。

结果：两组间的人口统计学价值、卵巢储备参数具有可比性。A组获卵数、MII期卵母细胞和双原核囊胚的数量较少。B组的妊娠率比A组高出2倍（23.4% vs. 50.9% p < .01）。妊娠率并不因B组中冷冻胚胎的数量而改变。

结论：根据结果, 冷冻胚胎的存在使新鲜囊胚移植患者的妊娠率更高, 这与妇女的年龄和卵巢储备无关。因此, 这些结果可能有助于我们在胚胎移植前预测植入率。

Keywords:

• Infertility
• intracytoplasmic sperm injection
• embryo transfer
• blastocyst
• fresh transfer

Disclosure statement

No potential conflict of interest was reported by the author(s).