The effects of coenzyme Q10 supplementation on metabolic profiles and parameters of mental health in women with polycystic ovary syndrome

Abstract

Objective

Evaluating the impact of coenzyme Q10 (CoQ10) supplementation on hormonal indices, mental health, and biomarkers of inflammatory responses and oxidative stress among female patients suffering from polycystic ovary syndrome (PCOS).

Methods

The present double-blinded, placebo-controlled randomized clinical trial consisted of 55 PCOS women (aged 18–40 years old), who were randomized into groups receiving 100 mg/day of CoQ10 (28 cases) or placebo (27 cases) for 12 weeks.

Results

The supplementation of CoQ10 decreased significantly the scores of Beck Depression Inventory (BDI) (p = .03) and Beck Anxiety Inventory (BAI) (p = .01) and high-sensitivity C-reactive protein (hs-CRP) level (p = .005) when comparing with the placebo group. Moreover, CoQ10 group exhibited a significant drop in total testosterone (p = .004), dehydroepiandrosterone sulfate (DHEAS) (p < .001), hirsutism (p = .002) and malondialdehyde (MDA) (p = .001) levels in the serum, and a significant rise in sex hormone-binding globulin (SHBG) (p < .001) and total antioxidant capacity (TAC) (p < .001) levels in the serum than the placebo group.

Conclusions

12-week supplementation of CoQ10 to PCOS women showed beneficial impact on BDI, BAI, hs-CRP, total testosterone, DHEAS, hirsutism, SHBG, TAC and MDA levels.

补充辅酶Q10对多囊卵巢综合征妇女代谢特征和心理健康参数的影响 摘要

目的：评估补充辅酶Q10 (CoQ10)对多囊卵巢综合征(PCOS)女性患者激素指标、心理健康、炎症反应和氧化应激的生物标志物的影响。

方法：采用双盲、安慰剂对照的随机临床试验研究55名PCOS女性(年龄18-40岁), 将受试者随机分为服用100 mg/天CoQ10的组(28例)和服用安慰剂的组(27例), 为期12周研究。

结果：与安慰剂组相比, 补充CoQ10显著降低Beck抑郁量表(BDI)得分(p = .03)和Beck焦虑量表(BAI)得分(p = .01)和高敏感性c -反应蛋白(hs-CRP)水平(p = .005)。此外, CoQ10组较安慰剂组血清中总睾酮(p = .004)、硫酸脱氢表雄酮(DHEAS) (p < .001)、多毛症(p = .002)和丙二醛(MDA) (p = .001)水平显著下降, 血清中性激素结合球蛋白(SHBG) (p < .001)和总抗氧化能力(TAC) (p < .001)水平显著高于安慰剂组。

结论：PCOS妇女补充CoQ10 12周显示对BDI、BAI、hs-CRP、总睾酮、DHEAS、多毛症、SHBG、TAC和MDA水平有有益影响。

Keywords:

• Coenzyme Q10
• mental health
• metabolic profiles
• polycystic ovary syndrome

Acknowledgments

The authors thank the staff of Akbarabadi Clinic (Tehran, Iran) for their assistance in this project.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Clinical trial registration number

http://www.irct.ir: IRCT20170513033941N36.

Additional information

Funding

This work was supported by the Iran University of Medical Sciences (97102).