Use of rotational thromboelastometry for a global screening of coagulation profile in patients of myeloproliferative neoplasms

Abstract

Chronic myeloproliferative neoplasms (MPN) are clonal disorders of hematopoietic stem/progenitor cell characterized by thrombohemorrhagic complications and a tendency to transform into acute leukemia. The pathogenesis of thrombosis in MPN is complex and results from a multifaceted interplay of clinical and disease-related factors. Rotational thromboelastometry (ROTEM) provides the complete and rapid information about all stages of the coagulation process. Here, we assess ROTEM parameters as a screening of coagulation profile in patients with MPNs. In particular, higher mean maximum clot firmness values were found in Essential thrombocythemia and Polycythemia vera patients when compared to healthy controls. Rotational thromboelastometry may be able to detect MPN patients who are susceptible to thrombotic and/or hemorrhagic complications. The predictive value of ROTEM for thrombosis remains to be established to classify subsets of patients at prominent risk who may benefit from prophylaxis with antithrombotic drugs.

Keywords:

• Essential thrombocythemia
• Myeloproliferative neoplasm
• Rotational thromboelastography

Author Contribution

Conception and design of the study: DGS, OMA; acquisition of data: DGS, EG, HUT, NA; analysis and/or interpretation of data: DGS, OMA; drafting the manuscript: DGS; revising the manuscript critically for important intellectual content: DGS, OMA.

Conflicts of Interest

The authors report no conflicts of interest.