Mechanisms of platelet release: in vivo studies and in vitro modeling

Abstract

Mechanisms related to platelet release in the context of the bone marrow niche are not completely known. In this review we discuss what has been discovered about four critical aspects of this process: 1) the bone marrow niche organization, 2) the role of the extracellular matrix components, 3) the mechanisms by which megakaryocytes release platelets and 4) the novel approaches to mimic the bone marrow environment and produce platelets ex vivo.

Acknowledgments

This paper was supported by H2020-FETOPEN-1-2016-2017-SilkFusion

Declaration of interests

The authors report no conflicts of interest

Additional information

Funding

This work was supported by the H2020 Future and Emerging Technologies [H2020-FETOPEN-1-2016-2017-SilkFusion - Project ID 767309].