Canonical correlation analysis on the association between HIV-related stress and health-related quality of life among newly diagnosed people living with HIV

ABSTRACT

The overall negative correlation between HIV-related stress and health related quality of life (HRQoL) among people living with HIV (PLWH) has been established, but less is known about the associations between them from various dimensions. We aimed to give a deep understanding of the relationship between these two multidimensional variables. A cross-sectional study of 557 PLWH with diagnosis less than 1 month was conducted. The HIV/AIDS Stress Scale (SS-HIV) and the Medical Outcomes Study HIV Survey (MOS-HIV) were used to assess the HIV-related stress and HRQoL, respectively. Canonical correlation analysis was performed to analyze their correlation. The association between HIV-related stress and HRQoL among PLWH was mainly determined by the emotional stress and four HRQoL dimensions including health transition, heath stress, mental health function and the attitude towards general quality of life, which should be taken as important considerations in the management of HIV.

KEYWORDS:

• HIV
• HIV-Related stress
• Health-Related Quality of Life
• Canonical Correlation Analysis

Acknowledgements

We would like to express gratitude to the survey respondents and the staff of Changsha Center for Disease Control and Prevention, Changsha Hospital for Infectious Disease Hospital, and those investigators from Xiangya School of Public Health, Central South University; for their kindest contributions and assistance to this study.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability statement

The data that support the findings of this study are available on request from the corresponding author, D L. The data are not publicly available due to their containing information that could compromise the privacy of research participants.

Ethics approval and consent to participate

The IEC of the Institute of Clinical Pharmacology at Central South University (CTXY-120033-3) approved this study, and all participants had provided written informed consent before participation.

Additional information

Funding

This work was supported by National Natural Science Foundation of China under grant number 81202290; and Natural Science Foundation of Hunan Province under grant number 2019JJ40401.

Notes on contributors

Yanlin Liu

LD contributed to the conceptualization and design of the study. PSJ, LYL, LD and MGW drafted the manuscript and made all revisions. Authors BFY and HYX contributed to the data analysis and the interpretation of the data, and provided critical input in the manuscript editing process. All authors read and approved the final manuscript.