Hemodynamic changes during conventional and daylight photodynamic therapy of actinic keratoses – a randomized controlled trial

Abstract

Background

Photodynamic therapy (PDT) is an effective treatment for actinic keratosis (AK). However, pain and hypertension are important side effects of conventional PDT (c-PDT). Several studies have demonstrated that daylight PDT (dl-PDT) is less painful while being as effective as c-PDT.

Objective

To observe the effect of c-PDT and dl-PDT on different hemodynamic parameters (systolic blood pressure and diastolic blood pressure, pulse rate, and peripheral oxygen saturation).

Methods

Fifty patients with AK on the head were enrolled into this prospective, randomized, controlled study and treated with c-PDT or dl-PDT in a 1:1 ratio. Hemodynamic parameters were measured at four different time points during treatment. Pain was quantified using a visual analog scale. AK was counted before treatment and after one month.

Results

C-PDT is associated with significantly more pain, a significant increase in blood pressure and a higher rate of patients with grade 3 hypertension. Whereas dl-PDT is almost painless and does not lead to any changes in hemodynamic parameters. For both treatments, a similar lesion response rate was found after one month.

Conclusions

dl-PDT has a better tolerability while being as effective as c-PDT and therefore may be the more favorable treatment option in certain patient groups.

Keywords:

• Photodynamic therapy
• blood pressure
• hypertension
• pain

Disclosure statement

AE receives funding by grant SFB/TR 156 of the DFG (Deutsche Forschungsgemeinschaft) and payment or honoraria by Janssen-Cilag, Biotest, MSD, and Galderma. AE is the president of the European Dermatology Forum (EDF). JH, AK, and PG declare that there is no conflict of interest.

Data availability statement

The data that support the findings of this study are available from the corresponding author upon reasonable request.