Design and synthesis of silver nanoparticle anchored poly(ionic liquid)s mesoporous for controlled anticancer drug delivery with antimicrobial effect

ABSTRACT

Owing to the importance of drug delivery, the synthesis of advanced nanomaterials for targeted drug delivery plays a considerable role in medical treatment. One of the most prominent nanomaterials is PIL, which is used as controlled anticancer drug delivery and significantly improves the half-life and antitumor effect. In this study, a stable and effective drug carrier containing silver nanoparticles was reported for the drug delivery with an antimicrobial effect, and the capability of the drug carrier . PILP was synthesized by radical polymerization, and silver nanoparticles were anchored into PIL voids by in-situ reduction, which developed the adsorption antimicrobial effect and capability of the drug carrier. The synthesized nanocomposite was characterized. The Ag-PILP nanocomposite showed antibacterial activityagainst both E. coli and S. aureus with a MIC of 256 μg/mL, and bactericidal activity against E. coli and S. aureus strains with a MBC of 256 and 512 μg/mL, respectively.

KEYWORDS:

• Anticancer drug
• antimicrobial
• drug delivery
• mesoporous nanomaterial
• polymeric ionic liquid
• silver nanoparticle

Acknowledgements

This study was supported by the Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran, Department of Radiation Oncology, Shahid Madani Hospital, Tabriz University of Medical Science, Tabriz, Iran, and Molecular Medicine Research Center, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by Tabriz University of Medical Sciences, Tabriz, Iran.