ABSTRACT
Cancer is the most frequently diagnosed disease-related cause of death among children and adolescents. This study was conducted to test association of occupational, environmental risk factors such as exposure to pesticides, radiations, hazardous chemicals and smoking among children with bone cancer. A retrospective case control study was conducted in Oncology center Mansoura University (OCMU). Study groups included bone cancer cases (n = 51) and an age and sex matched control group (n = 67). An interview-based questionnaire included demographic data, occupational and environmental risk factors for both children and parents. Exposure to n nitrose compounds from burning incense among children, paternal smoking and consanguinity are significantly different between cases and control. (p < 0.05). Paternal smoking and consanguinity are significant predictors for childhood bone cancer. It is recommended to add surveillance for environmental and occupational exposures to childhood bone cancer patients.
Authors’ contributions
El-Helaly S1 data collection and share in research writing Darwish A: Concept of study, share in research writing, preparing final manuscript, and approving the final manuscript.
Khashaba E: Concept and design of study, statistical analysis, preparing and submission of final manuscript. EL Domiaty H: Concept of study, revision of the manuscript and approving the final manuscript.
Disclosure statement
No potential conflict of interest was reported by the author(s).
Limitations of study
Bone cancer is one of rare cancers and the best fit design is case control study. Hence, an expected small sample based on single center study, difficulty to accurately reach definite exposure status and its level and recall bias. Further larger sample size studies are required.
Correction Statement
This article has been corrected with minor changes. These changes do not impact the academic content of the article.