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In vitro and animal studies

Apoptotic effect of a phytosterol-ingredient and its main phytosterol (β-sitosterol) in human cancer cell lines

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Pages 323-334 | Received 29 May 2018, Accepted 10 Aug 2018, Published online: 07 Sep 2018
 

Abstract

Dietary interventions may effectively control cancer development, with phytosterols (PS) being a class of cancer chemopreventive dietary phytochemicals. The present study, for the first time, evaluates the antiproliferative effects of a PS-ingredient used for the enrichment of several foods and its main PS, β-sitosterol, at physiological serum levels, in the most prevalent cancer cells in women (breast (MCF-7), colon (HCT116) and cervical (HeLa)). In all three cell lines, these compounds induced significant cell viability reduction without a clear time- and dose-dependent response. Moreover, all treatments produced apoptotic cell death with the induction of DNA fragmentation through the appearance of a sub-G1 cell population. Thus, the use of PS as functional ingredients in the development of PS-enriched foods could exert a potential preventive effect against human breast, colon and cervical cancer, although further in vivo studies are required to confirm our preclinical findings.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

Andrea Álvarez-Sala Martín holds grants for PhD study (ACIF/2015/251) and research stay (BEFPI/2016/046) from the Generalitat Valenciana (Spain).

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