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Abstract
Fish protein-derived bioactive peptides may improve endothelial dysfunction through an antihypertensive and antioxidant effect. However, few studies have evaluated the bioactive peptides effect on vascular function. Therefore, this study investigates the effect of a single dose of fish protein hydrolysate (FPH) or whey protein hydrolysates (WPH) on endothelium-dependent dilation in nine healthy adults. The subjects ingested a single dose (20 g) of FPH, WHP or placebo (PLA). The endothelium-dependent dilation was evaluated by flow-mediated dilatation before and at 30, 60 and 120 min after supplementation. Total antioxidant capacity (TAC) of the FPH and WPH supplements was evaluated by using the Trolox equivalent antioxidant capacity assay. There was a significant increase of endothelium-dependent dilation at 30 min after WPH but not after FPH as compared to PLA. There was a significant great TAC in FPH than WPH supplement. A single dose of FPH was not able to improve endothelium-dependent dilation compared to WPH.
Graphical Abstract
Acknowledgements
The authors thank Ricky Toledano for preparing the English version of the article.
Author contributions
GVO, MVS and EMC contributed substantially to volunteers’ recruitment and physiological analysis. TSA and CACJ contributed to the development of the fish protein hydrolysate supplement and reviewing the article. GVO contributed substantially to data acquisition, statistical analysis and data interpretation. GVO and MVS wrote the article. All authors read and approved the final article.
Disclosure statement
No potential conflict of interest was reported by the authors.