Advanced search
Publication Cover
International Journal of Food Sciences and Nutrition Volume 75, 2024 - Issue 1
Submit an article Journal homepage
279
Views
1
CrossRef citations to date
0
Altmetric
Studies in humans

Assessing the causal association between dietary vitamin intake and lymphoma risk: a Mendelian randomisation study

Mingming Zhoua Department of Epidemiology and Statistics, College of Public Health, Zhengzhou University, Zhengzhou, China;b Henan Key Laboratory of Tumor Epidemiology, Zhengzhou University, Zhengzhou, ChinaView further author information
,
Junfen Xiac Office of Health Care, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaView further author information
,
Xiaolin Chend Department of Prenatal Diagnosis Center, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaView further author information
,
Tiantian Wua Department of Epidemiology and Statistics, College of Public Health, Zhengzhou University, Zhengzhou, China;b Henan Key Laboratory of Tumor Epidemiology, Zhengzhou University, Zhengzhou, ChinaView further author information
,
Kedi Xua Department of Epidemiology and Statistics, College of Public Health, Zhengzhou University, Zhengzhou, China;b Henan Key Laboratory of Tumor Epidemiology, Zhengzhou University, Zhengzhou, ChinaView further author information
,
Yuanlin Zoua Department of Epidemiology and Statistics, College of Public Health, Zhengzhou University, Zhengzhou, China;b Henan Key Laboratory of Tumor Epidemiology, Zhengzhou University, Zhengzhou, ChinaView further author information
,
Shaobo Zhanga Department of Epidemiology and Statistics, College of Public Health, Zhengzhou University, Zhengzhou, China;b Henan Key Laboratory of Tumor Epidemiology, Zhengzhou University, Zhengzhou, ChinaView further author information
,
Pengxia Guoa Department of Epidemiology and Statistics, College of Public Health, Zhengzhou University, Zhengzhou, China;b Henan Key Laboratory of Tumor Epidemiology, Zhengzhou University, Zhengzhou, ChinaView further author information
,
Haoqing Chenga Department of Epidemiology and Statistics, College of Public Health, Zhengzhou University, Zhengzhou, China;b Henan Key Laboratory of Tumor Epidemiology, Zhengzhou University, Zhengzhou, ChinaView further author information
,
Saba Fidaa Department of Epidemiology and Statistics, College of Public Health, Zhengzhou University, Zhengzhou, China;b Henan Key Laboratory of Tumor Epidemiology, Zhengzhou University, Zhengzhou, ChinaView further author information
&
Chunhua Songa Department of Epidemiology and Statistics, College of Public Health, Zhengzhou University, Zhengzhou, China;b Henan Key Laboratory of Tumor Epidemiology, Zhengzhou University, Zhengzhou, China;e State Key Laboratory of Esophageal Cancer Prevention and Treatment, Zhengzhou University, Zhengzhou, ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-6028-5923View further author information
ORCID Icon show all
Pages 92-101 | Received 10 Jul 2023, Accepted 28 Oct 2023, Published online: 07 Nov 2023
 
Sample our Food Science & Technology journals, sign in here to start your access, latest two full volumes FREE to you for 14 days

Abstract

Observational studies of diet-related vitamins and lymphoma risk results were inconsistent. Our study aimed to estimate the causality between dietary vitamin intake and lymphoma through a Mendelian randomisation (MR) study. We enrolled dietary-related retinol, vitamin C, vitamin E, vitamin B6 and vitamin B12 as exposures of interest, with Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) as the outcome. The causal effects were estimated using inverse variance weighting (IVW), MR-Egger regression analysis and weighted median, supplemented by sensitivity analyses. The results revealed that genetically predicted dietary vitamin B12 intake was associated with a reduced HL risk (OR = 0.22, 95% CI 0.05–0.91, p = 0.036). The Q test did not reveal heterogeneity, the MR-Egger test showed no significant intercepts, and the leave-one-out (LOO) analysis did not discover any SNP that affect the results. No causal relationship about dietary vitamin intake on the NHL risk was observed.

Acknowledgments

We want to acknowledge the participants and investigators of the FinnGen study, the UK Biobank, the TAG, the Neale Lab, and the GIANT consortium.

Authors’ contributions

MZ and CS designed the research. JX, XC, TW, KX, YZ, SZ, PG, HC, and SF conducted the research. MZ analysed the data and wrote the manuscript. CS supervised the study conduct and reviewed the manuscript critically. All the authors read and approved the final version of the manuscript.

Disclosure statement

No potential competing interest was reported by the author(s).

Data availability statement

All data are publicly available. Summary GWAS statistics related to dietary vitamins are publicly available at https://gwas.mrcieu.ac.uk. FinnGen Consortium GWAS summary statistics for lymphoma are available at https://www.finngen.fi/en.

Additional information

Funding

This work was supported by Henan University Science and Technology Innovation Talents Support Program [19HASTIT005].

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 910.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.