Modeling the therapy system of noninvasive pressure support ventilation with the respiratory patient in COPD and ARDS

Abstract

The noninvasive pressure support ventilation (NPSV) has been one of mechanical ventilation widely applied for the respiratory patients in chronic obstructive pulmonary disease (COPD), acute respiratory distress syndrome (ARDS), etc. To investigate and develop the technologies in NPSV conveniently and in low-cost, in this article, a therapy system model of NPSV was designed with developing the mathematical submodels of NPSV respirator and respiratory patient in COPD and ARDS. By simulating the respirator, breath circuit, mask and respiratory patients, a MATLAB-based virtual experimental platform was developed for virtual ventilations. And in order to test the authenticity and practicability of the therapy system model of NPSV, a lot of ASL5000-based physical experiments were carried out for comparative analysis with the simulated outputs: pressures, flows and volumes. The statistical conclusions demonstrate that the simulated results are consist with the results from the physical experiments (TTEST P > 0.39). The experimental results tell that the therapy system model of NPSV is effective and workable. The developed therapy system model of NPSV will be beneficial for clinician and researcher to explore the therapeutic methods and some potential measures in NPSV for saving the respiratory patient’s health and life.

Keywords:

• Mathematical model
• therapy system model
• mechanical ventilation
• noninvasive pressure support ventilation

Acknowledgements

The authors would like to thank Prof. Huang Zhiliang for comments that greatly improved the manuscript.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This study is supported by a research grant: Hunan Provincial Natural Sciences Funding Project, China (2020JJ4159); Key research program of Hunan Provincial Education Department, China (19A093); Key program in researching digital diagnosis and treatment equipment supported by the Ministry of Science and Technology of China (2021YFC0122500).