Bone tissue growth in ultrasonically stimulated bioinspired scaffolds

Abstract

We develop computational models of bone growth in ultrasonically stimulated porous tissue scaffolds with uniform square pores and a bioinspired structure. While bone growth in the bioinspired scaffolds is slower, it produces amounts of bone comparable to the square pore scaffold, making the bioinspired structure ideal for enhancing bone growth with better structural integrity. Controlling the initial mesenchymal stem cell distribution in the scaffolds also affects the growth rate and total bone formation, which could be further useful for controlling bone growth in the scaffold based on an individual’s physiology.

Keywords:

• Bioinspired and porous scaffolds
• ultrasound wave transmission
• bone tissue growth
• computational model
• mesenchymal stem cells

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This research is supported by the 21^st Century Professorship grant from Department of Mechanical Engineering, University of Arkansas.