https://orcid.org/0000-0003-2500-4318
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ABSTRACT
Objective: The association between vitamin E supplementation and Alzheimer's disease (AD) was controversial because of conflicting data in the literature. This study was designed to systematically evaluate evidence about the efficacy of vitamin E supplementation not only on the risk but also on the progression of AD.
Design: Five electronic databases were searched for studies published up to June 2017. Articles reporting vitamin E supplementation and AD were included, and the random-effect model was performed for the meta-analysis about the relationship between vitamin E supplementation and AD.
Results: Five cohort studies and three randomized controlled trial (RCT) studies (total n = 14,262) involving 1313 cases about vitamin E effects on the risk of AD and 244 cases about effects on progression of AD. The pooled RR for vitamin E supplemental and risk of AD was 0.81 [95% CI: 0.50–1.33, I2 = 69.2%]. Suitable data could not be extracted to do meta-analysis as there was no unified standard of outcome measure for studies on AD progression. We carefully analyzed and evaluated the authenticity and accuracy of every single trial, while reliable evidence could not be obtained.
Conclusions: From what we do, neither the synthetic data on risk of AD nor the critical review on progression of AD could provide enough evidence on our research. Thus, we cannot draw a specific conclusion on the association or correlation between Vitamin E and AD.
Acknowledgements
W.Y and X.Z. directed the study and were involved in the study design. W.Y. and L.J. were involved in designing the search strategy, data collection and entry. W.Y. carried out the analysis. W.Y. and L.J. had the primary responsibility for drafting the manuscript and all authors contributed to writing and revising the manuscript. The authors are grateful to Dr X.Z. for her excellent assistance in the design of the paper and her comments on the manuscript.
Disclosure statement
No potential conflict of interest was reported by the authors.
Notes on contributors
Wanyu Wang is a master of Public Health and holds a major in food nutrition.
Jiao Li is a master of Nutrition and Food Hygiene and holds a major in human nutrition.
Huizhen Zhang is a professor of environmental toxicology and writes on reproductive toxicology. One of her recent books is Health care (Zhengzhou, 2011).
Xiaokai Wang is a master of Nutrition and Food Hygiene and holds a major in human nutrition.
Xiaofeng Zhang is an associate professor of nutrition and writes on both food nutrition and dietary guidelines in the public health. Among her recent books are Guidelines on nutrition and reasonable diet for students (Beijing, 2014) and Food safety (belongs to the Series of Books on Science and General Inspection) (Zhengzhou, 2013).