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Journal of Asian Natural Products Research Volume 21, 2019 - Issue 5
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Original Articles

Puerarin prevents diabetic cardiomyopathy in vivo and in vitro by inhibition of inflammation

Mao-Shan YinCenter for Drug Evaluation, Food and Drug Administration, Beijing100038, China;Key Laboratory for Rare Disease of Shandong Province, Department of Pharmacology, Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, China
,
Yi-Chi ZhangDepartment of Pharmacy, Jinan Children’s Hospital, Jinan250022, China
,
Shu-Hong XuState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing100050, China
,
Jing-Jing LiuKey Laboratory for Rare Disease of Shandong Province, Department of Pharmacology, Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, China
,
Xiao-Hui SunKey Laboratory for Rare Disease of Shandong Province, Department of Pharmacology, Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, China
,
Chen LiangKey Laboratory for Rare Disease of Shandong Province, Department of Pharmacology, Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, China
,
Yan WangKey Laboratory for Rare Disease of Shandong Province, Department of Pharmacology, Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, China
,
Jie LiKey Laboratory for Rare Disease of Shandong Province, Department of Pharmacology, Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, China
,
Fu-Wen WangKey Laboratory for Rare Disease of Shandong Province, Department of Pharmacology, Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, China
,
Qing-Li WangCenter for Drug Evaluation, Food and Drug Administration, Beijing100038, China
&
Yan-Ling MuKey Laboratory for Rare Disease of Shandong Province, Department of Pharmacology, Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, ChinaCorrespondence[email protected]
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Pages 476-493 | Received 04 Sep 2017, Accepted 13 Nov 2017, Published online: 11 Jan 2018
 
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Abstract

Diabetic cardiomyopathy (DCM) is one of the chief diabetes mellitus complications. Inflammation factors may be one reason for the damage from DM. The purpose of this research is to study the potential protective effects of puerarin on DM and the possible mechanisms of action related to NF-κB signal pathway. Following administration of puerarin to the disease model rat, several changes were observed including the changes of serum biochemical index, improved diastolic dysfunction, and enhanced endogenous antioxidant enzymes activities, further NF-κB signaling activation. Puerarin showed cardio-protective effects on DCM by inhibiting inflammation, and it might be a potential candidate for the treatment of DCM.

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