A new lindenane-type sesquiterpenoid lactone from Chloranthus japonicus

Abstract

Chromatographic fractionation of the EtOH extracts of the Traditional Chinese Medicine (TCM) Chloranthus japonicus, has led to the isolation of a new lindenane-type sesquiterpenoid lactone derivative (1). Rosmarylchloranthalactone E (1), which consists of lindenane sesquiterpenoid lactone and rosmarinic acid moieties linked via an ester bridge, was structurally elucidated by 1D and 2D NMR and HRMS data. Compound 1 was a potent phosphodiesterase-4 (PDE4) inhibitor with an IC₅₀ value of 0.96 ± 0.04 μM.

Keywords:

• Chloranthaceae
• Chloranthus japonicus
• lindenane-type sesquiterpenoid
• rosmarylchloranthalactone E
• phosphodiesterase-4

Acknowledgements

The authors acknowledge the financial support from the Young Taishan Scholars Program [grant number tsqn20161037], the National Natural Science Foundation of China [grant number 81402813], [grant number 81573302], the National High Technology Research and Development Program of China (863 Project) [grant number 2015AA020928], and the Guangdong Natural Science Funds for Distinguished Young Scholar [grant number 2014A030306047].