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Journal of Asian Natural Products Research Volume 21, 2019 - Issue 4
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Articles

A new phenanthrene dimer from Dendrobium palpebrae

Napat KyokongFaculty of Pharmaceutical Sciences, Department of Pharmacognosy and Pharmaceutical Botany, Chulalongkorn University, Bangkok10330, Thailand
,
Chawanphat MuangnoiPharmaceutical Chemistry and Natural Products Program, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok10330, Thailand;Natural Products for Ageing and Chronic Diseases Research Unit, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok10330, Thailand
,
Wuttinont ThaweesestPharmaceutical Chemistry and Natural Products Program, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok10330, Thailand;Natural Products for Ageing and Chronic Diseases Research Unit, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok10330, Thailand
,
Virunh KongkatithamFaculty of Pharmaceutical Sciences, Department of Pharmacognosy and Pharmaceutical Botany, Chulalongkorn University, Bangkok10330, Thailand
,
Kittisak LikhitwitayawuidFaculty of Pharmaceutical Sciences, Department of Pharmacognosy and Pharmaceutical Botany, Chulalongkorn University, Bangkok10330, Thailand
,
Pornchai RojsitthisakNatural Products for Ageing and Chronic Diseases Research Unit, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok10330, Thailand;Faculty of Pharmaceutical Sciences, Department of Food and Pharmaceutical Chemistry, Chulalongkorn University, Bangkok10330, Thailand
&
Boonchoo SritularakFaculty of Pharmaceutical Sciences, Department of Pharmacognosy and Pharmaceutical Botany, Chulalongkorn University, Bangkok10330, Thailand;Natural Products for Ageing and Chronic Diseases Research Unit, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok10330, ThailandCorrespondence[email protected]
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Pages 391-397 | Received 17 Dec 2017, Accepted 15 Jan 2018, Published online: 25 Jan 2018
 
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Abstract

A new phenanthrene dimer, namely dendropalpebrone (1), was isolated from the whole plant of Dendrobium palpebre, along with nine known compounds (2–10). All of the isolates were evaluated for their hydroxyl radical scavenging effects using a deoxyribose assay. Dendroflorin (10) showed an appreciable activity, and therefore was selected for further studied in RAW264.7 cells. Compound 10 significantly decreased ROS in H2O2-stimulated RAW264.7 cells in a dose-dependent manner, and improved activity of SOD, GPx, and CAT enzymes.

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