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Journal of Asian Natural Products Research Volume 21, 2019 - Issue 6
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New polyacetylenes glycoside from Eclipta prostrate with DGAT inhibitory activity

Xiao Meng College of Pharmacy, Beihua University , Jilin132013, China
,
Ban-Ban Li College of Pharmacy, Beihua University , Jilin132013, China
,
Xin Lin College of Pharmacy, Beihua University , Jilin132013, China
,
Yi-Yu Jiang College of Pharmacy, Beihua University , Jilin132013, China
,
Le Zhang College of Pharmacy, Beihua University , Jilin132013, China
,
Hao-Ze Li College of Pharmacy, Beihua University , Jilin132013, China
&
Long Cui College of Pharmacy, Beihua University , Jilin132013, ChinaCorrespondence[email protected]
 show all
Pages 501-506 | Received 20 Sep 2017, Accepted 11 Mar 2018, Published online: 08 Jun 2018
 
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Abstract

One new polyacetylene glycoside eprostrata Ⅰ (1), together with seven known compounds (2–8), were isolated from Eclipta prostrata. Their structures were elucidated on the basis of spectroscopic and physico-chemical analyses. All the isolates were evaluated inhibitory activity on DGAT in an in vitro assay. Compounds 1–8 were found to exhibit inhibitory activity of DGAT1 with IC50 values ranging from 74.4 ± 1.3 to 101.1 ± 1.1 μM.

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