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Journal of Asian Natural Products Research Volume 21, 2019 - Issue 1
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A new para-quinone-type flavan from the leaves of Ilex centrochinensis and its anti-inflammatory activities

Hui LongNational & Local Joint Engineering Research Center for High-throughput Drug Screening Technology, Wuhan430062, China;Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources, Wuhan430062, China
,
Qin-Fang YanNational & Local Joint Engineering Research Center for High-throughput Drug Screening Technology, Wuhan430062, China;Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources, Wuhan430062, China
,
Ze-Hua HuMedical School, Hubei University for Nationalities, Enshi445000, China
,
Qiang ZhangNational & Local Joint Engineering Research Center for High-throughput Drug Screening Technology, Wuhan430062, China;Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources, Wuhan430062, China
,
Yu ChenNational & Local Joint Engineering Research Center for High-throughput Drug Screening Technology, Wuhan430062, China;Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources, Wuhan430062, China
&
Lu-Jun LiNational & Local Joint Engineering Research Center for High-throughput Drug Screening Technology, Wuhan430062, China;Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources, Wuhan430062, China;Hubei Key Laboratory of Bio-Technology of Traditional Chinese Medicine, Hubei University, Wuhan430062, ChinaCorrespondence[email protected]
Pages 86-92 | Received 04 Dec 2017, Accepted 14 Mar 2018, Published online: 28 Mar 2018
 
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Abstract

A new para-quinone-type flavan, (2S)-7-methoxy-3′,4′-dihydroxy-5,8-quinoflavan (1), together with three known compounds, were isolated from the leaves of Ilex centrochinensis. Their structures were elucidated by detailed spectroscopic analyses for new structure and in comparison with published data for known compounds. Moreover, the new compound was evaluated its cytotoxic and anti-inflammatory activities in vitro on LPS induced RAW 264.7 cells and the results showed that 1 has promising anti-inflammatory activities.

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