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Journal of Asian Natural Products Research Volume 21, 2019 - Issue 6
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New dianthramide and cinnamic ester glucosides from the roots of Aconitum carmichaelii

Thi Quynh Do Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) , Hanoi100000, Vietnam
,
Bich Ngan Truong Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) , Hanoi100000, Vietnam
,
Huong Doan Thi Mai Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) , Hanoi100000, VietnamCorrespondence[email protected]
,
Thuy Linh Nguyen Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) , Hanoi100000, Vietnam
,
Van Hung Nguyen Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) , Hanoi100000, Vietnam
,
Hai Dang Nguyen Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) , Hanoi100000, Vietnam
,
Tien Dat Nguyen Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) , Hanoi100000, Vietnam; Center for Research and Technology Transfer, VAST , Hanoi100000, Vietnam
,
The Cuong Nguyen Institute of Ecology and Biological Resources, VAST , Hanoi100000, Vietnam
,
Trieu Vung Luong Department of Agriculture and Rural Development of Ha Giang , Ha Giang310000, Vietnam
,
Loc Thang Giang Pho Bang Centre for Plant and Animal Varieties , Ha Giang310000, Vietnam
,
Van Minh Chau Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) , Hanoi100000, Vietnam
&
Van Cuong Pham Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) , Hanoi100000, VietnamCorrespondence[email protected]
 show all
Pages 507-515 | Received 21 Sep 2017, Accepted 14 Mar 2018, Published online: 30 Mar 2018
 
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Abstract

Four new compounds N-salicyl-3-hydroxyanthranilic acid methyl ester (1), N-(2′-dehydroxysalicyl)-3-hydroxyanthranilic acid methyl ester (2), methyl-4-β-D-allopyranosyl-ferulate (3), and methyl-4-β-D-gulopyranosyl-cinnamate (4), along with six known compounds (5–10), were isolated from the roots of Aconitum carmichelii Debx. Their structures were elucidated on the basis of spectral data analysis, including 1D, 2D-NMR, and HR-ESI-MS. Compounds 1 and 2 showed the inhibition of nitric oxide (NO) production with IC50 values of 9.13 and 19.94 μM, respectively.

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