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Journal of Asian Natural Products Research Volume 21, 2019 - Issue 8
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Original Articles

Alkaloids from Melodinus henryi with anti-inflammatory activity

Jin-Qian YuShandong Key Laboratory of TCM Quality Control Technology, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan250014, ChinaCorrespondence[email protected]
,
Xiao-Wei SunSchool of Chemistry and Pharmaceutical Engineering, Qilu University of Technology, Jinan250014, China
,
Zhi-Wei WangShandong Key Laboratory of TCM Quality Control Technology, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan250014, China
,
Lei FangCollege of Biological Sciences and Technology, University of Jinan, Jinan250022, China
&
Xiao WangShandong Key Laboratory of TCM Quality Control Technology, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan250014, China;School of Chemistry and Pharmaceutical Engineering, Qilu University of Technology, Jinan250014, ChinaCorrespondence[email protected]
Pages 820-825 | Received 11 Dec 2017, Accepted 27 May 2018, Published online: 22 Jun 2018
 
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Abstract

One new quinolinic scandine-type monoterpeniod alkaloid, 3-oxo-scandine (1), as well as seven known ones (2–8), was isolated from the roots of Melodinus henryi. Their structures were elucidated by extensive spectroscopic analysis. All of the compounds were prepared and evaluated for their anti-inflammatory activities by measuring the inhibitory activity of nitric oxide (NO) in vitro in RAW 264.7 mouse peritoneal macrophages. Compounds 6 and 7 showed significant activities with IC50 values of 8.54 and 5.19 μM, respectively.

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