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Journal of Asian Natural Products Research Volume 21, 2019 - Issue 10
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Original Articles

Sesquiterpenoids with cytotoxicity from heartwood of Dalbergia odorifera

Hui Meng Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing, China; Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine, Hainan Branch Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College , Haikou, China
,
De-Li Chen Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine, Hainan Branch Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College , Haikou, China
,
Yun Yang Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine, Hainan Branch Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College , Haikou, China
,
Yang-Yang Liu Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine, Hainan Branch Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College , Haikou, ChinaCorrespondence[email protected] [email protected]
&
Jian-He Wei Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing, China; Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine, Hainan Branch Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College , Haikou, ChinaCorrespondence[email protected] [email protected]
Pages 954-960 | Received 27 Jan 2018, Accepted 15 Jun 2018, Published online: 26 Jul 2018
 
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Abstract

Two new sesquiterpenoids, named dalodorin A (1) and dalodorin B (2), together with four known sesquiterpenoids, were isolated from the heartwood of Dalbergia odorifera. Their structures were elucidated on the basis of spectroscopic analysis including 1D and 2D NMR techniques and HR-ESI-MS. Evaluation of the isolated compounds for cytotoxicity against two human cancer cell lines (Hela and HepG-2) showed moderate activities (25.22–60.45 μM).

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