New ingol-type diterpenes from the latex of Euphorbia resinifera

Abstract

Two new ingol-type diterpenes, euphoresins A–B (1–2), have been isolated from the methanol extract of Euphorbium, the latex of Euphorbia resinifera Berg. Their structures were established on the basis of extensive analyses of their HR-ESI-MS, IR, UV, 1D, and 2D NMR spectra. The absolute configurations were confirmed by Mosher’s method and circular dichroism (CD) analyses. The two compounds were tested for their cytotoxic activities against MCF-7, U937, and C6 cancer cell lines, but they both exhibited little cytotoxic effect.

Graphical Abstract

Keywords:

• Euphorbium
• euphorbia
• ingol-type diterpenes
• cytotoxicity

Acknowledgements

This work received the support of Key Projects of the National Science and Technology Pillar Program (2012BAI30B02) and National Science and Technology Major Projects for New Drug Development (2018ZX09305005). We are grateful to Prof. Yong Tan for identification of the plant material.

Supplementary data

The 1D NMR, 2D NMR, IR, MS and HR-ESI-MS spectra for compounds 1, 2 were available in the Supplementary data.

Additional information

Funding

This work received the support of Key Projects of the National Science and Technology Pillar Program (2012BAI30B02) and National Science and Technology Major Projects for New Drug Development (2018ZX09305005).