Chemical constituents from the whole herb of Hemiphragma heterophyllum

Abstract

Phytochemical investigation on Hemiphragma heterophyllum led to the isolation of two new compounds, heterophyllumin A (1) and heterophylliol (3), along with nine known compounds, (‒)-sibiricumin A (2), iridolactone (4), jatamanin A (5), dihydrocatalpolgenin (6), 25-hydroperoxycycloart-23-en-3β-ol (7), 24-methylenecycloartanol (8), (+)-pinoresinol (9), hexadec-(4Z)-enoic acid (10), and 9,12, 15-octadecatrienoic acid (11). Their structures were elucidated on the basis of detailed spectroscopic analyses and by comparison with literature data. Further, the structure of compound 3 was unambiguously confirmed by single-crystal X-ray analysis. Some of those compounds showed moderate activity in the α-glucosidase inhibition assay.

Keywords:

• Scrophulariaceae
• Hemiphragma heterophyllum
• sesquineolignans
• iridoids
• α-glucosidase inhibitory activity

Supporting information

Detailed experimental procedures, 1D and 2D NMR, HRMS, IR, UV spectra, and X-ray crystal data are provided.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by the NSFC [grant number 81460535], the Natural Science Foundation of Yunnan Province [grant number Y0120160159], the Yunnan Provincial Department of Education Science Research Fund Project [grant number 2017YJS058], and the Yunnan Provincial Applied Basic Research Projects [grant number 2017FD122].