Efficacy of phospholipidated curcumin in nonalcoholic fatty liver disease: a clinical study

Abstract

Curcumin is a safe and dietary phytochemical that can improve different pathophysiologic features of non-alcoholic fatty liver disease (NAFLD). Here, we investigated the efficacy of phospholipidated curcumin supplementation in NAFLD patients. In this single-arm study, 36 patients were recruited. Each patient received three capsules a day (each containing 500 mg of phospholipidated curcumin [overall content of curcuminoids per capsule: 100 mg]) for a period of 8 weeks. The results indicated that phospholipidated curcumin supplementation reduced NAFLD severity and ameliorated ultrasonographic and biochemical measures (including liver transaminases and lipid profile) associated with disease progression.

Graphical Abstract

Keywords:

• Non-alcoholic fatty liver disease
• curcumin
• clinical trial
• dyslipidemia

Acknowledgement

The authors would like to thank the Gastroenterology and Hepatology Clinic of the Shaheed Baghaee Hospital (Ahvaz, Iran) and Indena SpA (Milan, Italy) for their support.

Disclosure statement

The authors have no competing interests to declare.