A new flavanol from the roots of Daphne genkwa

Abstract

The phytochemical investigation of the roots of Daphne genkwa yielded six secondary metabolites, including a new flavanol derivative, (2R, 3S)-5,7,4′-trihydroxy-8-methoxycarbonylflavanol (1), and five known compounds (2–6). The molecular structures of the isolated constituents were elucidated on the basis of extensive spectroscopic analysis, including UV, IR, NMR, and MS, and comparison with literature data. Furthermore, the cytotoxic activity of 1 and 2 against A549, HL-60, SMMC-7721, MCF-7, and SW480 cell lines was also described.

Graphical Abstract

Keywords:

• Daphne genkwa
• Thymelaeaceae
• flavanol
• structure
• cytotoxic activity

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by the National Natural Science Foundation of China (No. 81303202) and the Research and Development Project of the Colleges in Shandong Province (No. J17KA251).