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Abstract
This study aimed at investigating the pharmacokinetics (PK) and acetylcholine (Ach) releasing effects of ginsenoside Rg1 in hippocampus (HIP) of soluble oligomeric assemblies of amyloid beta (ADDLs) induced Alzheimer’s disease (AD) model rats. Extracellular fluid was collected by microdialysis technique. The concentrations of Rg1 and Ach in dialysates were detected by liquid chromatography–tandem mass spectrometry (LC–MS/MS) method. The results showed, after administration, Rg1 was soon detected in the HIP of model rats and extracellular Ach concentrations in the HIP were significantly increased.
Graphical Abstract
Disclosure statement
No potential conflict of interest was reported by the authors.
Geolocation information
Department of Pharmacy, Peking University People’s Hospital, Beijing 100044, China.
Additional information
Funding
This work was funded by the Natural Science Foundation of China [grant number 81303250].