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Journal of Asian Natural Products Research Volume 22, 2020 - Issue 3
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A new xanthyletin-type coumarin from the roots of Peucedanum praeruptorum

Xin-Yu LiKey Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China;
,
Yuan-Yuan ZuKey Laboratory of Zoonosis of Liaoning Province, School of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China;
,
Wei NingCollege of Horticulture, Shenyang Agricultural University, Shenyang 110866, China
,
Ming-Xu TangKey Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China;
,
Chi GongKey Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China;
,
Sheng-Li NiuKey Laboratory of Zoonosis of Liaoning Province, School of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China; Correspondence[email protected] [email protected]
&
Hui-Ming HuaKey Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China;
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Pages 287-294 | Received 25 Feb 2018, Accepted 20 Nov 2018, Published online: 08 Jan 2019
 
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Abstract

A new xanthyletin-type coumarin, neopeucedalactone (1), was isolated from the roots of Peucedanum praeruptorum Dunn. Its chemical structure was elucidated based on extensive spectroscopic interpretation. The absolute configurations of xanthyletin-type coumarin were determined by comparing experimental and calculated ECD spectra for the first time. Compound 1 exhibited moderate cell growth inhibitory activities in vitro against human leukemic HL-60, THP-1 cell lines, and human prostate cancer PC-3 cell lines, with IC50 values of 9.97, 27.80, and 48.68 µM, respectively.

Acknowledgments

The authors are grateful to Mr. Jingchao Liu and Mr. Zishuang Liu (Analytical Testing Center, Northeast University, Shenyang, China) for their measurements of the NMR data.

Disclosure statement

No potential conflict of interests was reported by the authors.

Funding

Financially support of this investigation by Scientific Research Foundation of Shenyang Agricultural University (Grant No. 880415026) is gratefully acknowledged.

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