A new bioactive coumestan from the seeds of Psoralea corylifolia

Abstract

A new coumestan named bavacoumestan D (1), together with five known compounds (2-6), was isolated from EtOAc-soluble extract of seeds of Psoralea corylifolia. Their structures were elucidated on the basis of spectroscopic and physico-chemical analyses. All compounds were evaluated for in vitro inhibitory activity against DGAT1, DGAT2 and α-glucosidase. Among them, compounds 1–2, 5–6 showed potential inhibitory activity on DGAT1 with IC₅₀ values ranging from 52.3 ± 1.3 to 81.0 ± 1.0 μM. Compounds 1–3, 6 displayed the significant inhibitory activity on α-glucosidase with IC₅₀ values ranging from 31.2 to 89.1 μM.

Keywords:

• Leguminosae
• Psoralea corylifolia
• obesity
• coumestan
• DGAT
• α-glucosidase

Disclosure statement

No potential conflict of interest was reported by the author.

Funding

This work was financially supported by the National Science and Technology Major Project [grant number 2013ZX09303–012].