Bioactive phenolic acid-substituted glycoses and glycosides from rhizomes of Cibotium barometz

Abstract

Two rarely phenolic acid-substituted alloses (1, 2) and one new glucoside (3), as well as nine known compounds (4–12) were isolated from rhizomes of Cibotium barometz (L.) J. Sm. Structures of 1–3 were established by extensively spectroscopic analyses (NMR, MS, etc.) and acid hydrolysis. All compounds were evaluated for the hepatoprotective activities against APAP-induced HepG2 cell damage. Compounds 1, 4–7, 10 exhibited significant hepatoprotective activities, even more strongly than positive control, bicycol. In addition, compounds 1 and 9 could reduce PC12 cell death induced by serum deprivation.

Keywords:

• Cibotium barometz
• phenolic acid
• allose
• hepatoprotection

Acknowledgments

The authors greatly thank Prof. Xiaoguang Chen (cytotoxicity), Prof. Naihong Chen (neuroprotection), Prof Fei Ye (XOD), and Prof Qi Hou (anti-inflammation) for conducting the bioassay experiments.

Disclosure statement

The authors declare that they have no competing interests.

Additional information

Funding

This work was financially supported by the CAMS Innovation Fund for Medical Sciences (CIFMS) No. 2016-I2M-3-011.