Three new compounds from Dictamnus dasycarpus and their anti-inflammatory activities

Abstract

Three new compounds (1–3), named dasycarine G (1), dasycarether (2), and dasycarester (3), along with seven known compounds (4–10) obtained from the genus Dictamnus for the first time, were isolated from the root bark of Dictamnus dasycarpus. Their structures were elucidated on the basis of spectroscopic data (UV, IR, HR-ESI-MS, 1D and 2D NMR, and CD). In the in vitro assay, compounds 1, 5, 6, 9, and 10 exhibited NO inhibitory effects of LPS-induced BV-2 cells with IC₅₀ values in the range of 10.4 μM to 27.2 μM.

Graphical Abstract

Keywords:

• Dictamnus dasycarpus
• Rutaceae
• alkaloids
• anti-inflammatory effect

Disclosure statement

The authors declare no conflict of interest.

Additional information

Funding

This work was financially supported by National Key Technology R&D Programs “New Drug Innovation” of China (No. 2018ZX09711001-008-003) and National Traditional Chinese Medicine Standardization Project (No. 2017-110108-83-03-001423).