Four new caffeoylgluconic acid positional isomers from the fruits of Evodia rutaecarpa

Abstract

Four new compounds, 4-O-trans-caffeoylgluconic acid (1), 2-O-trans-caffeoylgluconic acid (2), 3-O-trans-caffeoylgluconic acid (3), 5-O-trans-caffeoylgluconic acid (4), together with three known ones including 6-O-trans-caffeoylgluconic acid (5), neochlorogenic acid (6), chlorogenic acid (7) were obtained from the fruits of Evodia rutaecarpa. Their structure elucidation was achieved by the methods of spectroscopic analyses, including HR-ESI-MS, NMR, and by comparison with literatures. The hepatotoxicity of compounds 1–3 was evaluated by CCK-8 method.

Keywords:

• Evodia rutaecarpa
• positional isomers
• caffeoylgluconic acid
• hepatotoxicity
• L02 cell

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by the Shandong Provincial Major Scientific and Technological Innovation Project (2017CXGC1301 and 2017CXGC1308); National Major Fundamental Research Program of China (2009CB522802); Natural Science Foundation of Shandong Province (ZR2016HQ17 and ZR2016HQ49); The Taishan Scholar Program of Shandong Province (Project No. ts201511107).