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Journal of Asian Natural Products Research Volume 22, 2020 - Issue 9
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Articles

The synergistic anti-tumor effect of schisandrin B and apatinib

Ya-Jing Lia Department of Pharmacy, Hebei General Hospital, Shijiazhuang050051, ChinaORCID Iconhttps://orcid.org/0000-0002-7118-4658
ORCID Icon,
Hong-Tao Liua Department of Pharmacy, Hebei General Hospital, Shijiazhuang050051, China
,
Chao-Jun Xuea Department of Pharmacy, Hebei General Hospital, Shijiazhuang050051, China
,
Xiao-Qin Xinga Department of Pharmacy, Hebei General Hospital, Shijiazhuang050051, China
,
Song-Tao Donga Department of Pharmacy, Hebei General Hospital, Shijiazhuang050051, China
,
Lin-Shan Wanga Department of Pharmacy, Hebei General Hospital, Shijiazhuang050051, China
,
Cong-Yang Dinga Department of Pharmacy, Hebei General Hospital, Shijiazhuang050051, China;b Graduate School of Hebei Medical University, Shijiazhuang050017, China
,
Lu Menga Department of Pharmacy, Hebei General Hospital, Shijiazhuang050051, China;b Graduate School of Hebei Medical University, Shijiazhuang050017, China
&
Zhan-Jun Donga Department of Pharmacy, Hebei General Hospital, Shijiazhuang050051, China;b Graduate School of Hebei Medical University, Shijiazhuang050017, ChinaCorrespondence[email protected]
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Pages 839-849 | Received 10 Jan 2019, Accepted 15 Jul 2019, Published online: 31 Jul 2019
 
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Abstract

The synergistic anti-tumor effect of schisandrin B (Sch.B) and apatinib was investigated in vitro. The CCK-8 assay revealed that Sch.B enhanced the inhibition of apatinib on cell proliferation by arresting cell cycle in G0/G1 phase. Sch.B also potentiated the suppression of apatinib on cell migration and invasion, by means of wound-healing and transwell invasion assay. Flow cytometry results showed that Sch.B enhanced apoptosis induced by apatinib. The results were confirmed by western blot analysis of the proteins MMP-9, and Bax caspase-9, and -12. These results suggest that combining apatinib and Sch.B is an effective therapeutic strategy for preventing GC progression.

Disclosure statement

No potential conflict of interest was reported by the authors.

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