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Journal of Asian Natural Products Research Volume 22, 2020 - Issue 3
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Articles

Seven new 1-oxygenated cholestane glycosides from Ornithogalum saundersiae

Qing-Wei ChenState Key Laboratory of Bioactive Substance and Function of Natural Medicines & NHC Key Laboratory of Biosynthesis of Natural Products, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, ChinaView further author information
,
Ting- GongState Key Laboratory of Bioactive Substance and Function of Natural Medicines & NHC Key Laboratory of Biosynthesis of Natural Products, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, ChinaView further author information
,
Pei-Cheng ZhangState Key Laboratory of Bioactive Substance and Function of Natural Medicines & NHC Key Laboratory of Biosynthesis of Natural Products, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, ChinaCorrespondence[email protected] [email protected]
View further author information
&
Jian-Qiang KongState Key Laboratory of Bioactive Substance and Function of Natural Medicines & NHC Key Laboratory of Biosynthesis of Natural Products, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, ChinaView further author information
Pages 201-216 | Received 17 May 2019, Accepted 10 Aug 2019, Published online: 09 Sep 2019
 
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Abstract

As the continuous scientific research, seven new 1-oxygenated cholestane glycosides named osaundersiosides 1 A − 1 G were isolated from an EtOH extract of the bulbs of Ornithogalum saundersiae. Their structures were deduced by means of spectroscopic data, chemical evidence and the results of hydrolytic cleavage. The cytotoxicity and anti-inflammatory effects of osaundersiosides 1 A − 1 G were evaluated, but none of them displayed significant activities.

Disclosure statement

The authors declare no conflict of interest.

Additional information

Funding

This work was financially supported by the Drug Innovation Major Project (2018ZX09711001-006), CAMS Innovation Fund for Medical Sciences (CIFMS) (2016-I2M-3-012) and Beijing Natural Science Foundation (7172143).

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