Two new furofuran lignan glycoside derivatives from the fruit of Forsythia suspensa

Abstract

Phytochemical investigation of 95% ethanol extract of the fruit of Forsythia suspensa resulted in the isolation of two new furofuran lignan glycoside derivatives pinoresinoside A (1) and phillyrigeninside A (2), along with three known ones. Their structures were established based on extensive spectroscopic data analyses and comparison with literature data. Absolute configuration of 1 was determined by CD method. In addition, compounds 1 and 2 were revealed to show in vitro cytotoxicity against human tumor cell lines (SGC-7901, MCF-7 and HepG2), with IC₅₀ values ranging from 16.77 to 37.35 µM.

Keywords:

• Furofuran lignan glycoside
• Forsythia suspensa
• cytotoxicity

Acknowledgments

This work was financially supported by China Postdoctoral Science Foundation 2018M631965, Hei Long Jiang Postdoctoral Foundation and National Natural Science Foundation of China 81803696.

Disclosure statement

The authors declare no conflicts of interest.