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Original Articles

Cytotoxic gelsedine-type indole alkaloids from Gelsemium elegans

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Pages 1138-1144 | Received 05 Aug 2019, Accepted 11 Nov 2019, Published online: 08 Jan 2020
 

Abstract

A chemical investigation on the 95% ethanol extract of the aerial part of Gelsemium elegans resulted in the isolation of three new gelsedine-type indole alkaloids, 14β-hydroxygelselenidine (1), 11-methoxygelseziridine (2), and 14β-hydroxygelsedethenine (3). Structural elucidation of all the compounds was accomplished by spectral methods such as 1 D and 2 D NMR, IR, UV, and HRESIMS. The isolated compounds were tested in vitro for cytotoxic activities against five human non-small-cell lung cancer cell lines. Consequently, alkaloid 3 exhibited cytotoxic activities for all tested tumor cell lines with IC50 values from 8.3 to 9.8 μM.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was funded by Science and Technology Plan Project in Nantong City (No. ms12017005-2).

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